Published in Leading Scientific Journals
Advancing Biomedical Research through Innovation
AUM Biotech's revolutionary nucleic acids platform for gene silencing and regulation
Revolutionary Technology
AUMsilence platform employs next-generation chemical modifications and AI-driven design to achieve remarkable stability and activity, effectively silencing genes with unprecedented precision.
Self-Delivering
sdASO™ reagents are self-delivering — simply add them to cell culture or inject them in vivo without transfection reagents, electroporation, or viral vectors.
Broad Compatibility
Works across a wide range of cell types and organisms, from cell lines to primary patient cells and animal models, achieving consistent gene knockdown where other methods fail.
Key Advantages Over RNAi and Gene-Editing
AUM BioTech's platform offers multiple advantages that set it apart from siRNA, shRNA, and CRISPR-based methods
Transfection-Free Delivery
sdASO™ reagents are self-delivering — you can simply add them to cell culture or inject them in vivo without the need for lipid transfection reagents, electroporation, or viral vectors.
Broad Compatibility
AUM BioTech's sdASO™ products work across a wide range of cell types and organisms, from cell lines to primary patient cells and animal models, achieving consistent gene knockdown.
High Specificity & Low Off-Target Effects
AUMsilence antisense oligos are designed for maximum sequence specificity, drastically reducing off-target gene effects for cleaner results and more reliable data.
Safety and Non-Toxicity
Because no transfection agents or viral vehicles are required, cellular stress is minimized with no overt toxicity or immune activation in cells and animals.
Rapid, Scalable, and Reversible
Gene silencing is as simple as adding a reagent — no need to construct plasmids or engineer cell lines, saving weeks compared to CRISPR or shRNA workflows.
In-Depth Control and Versatility
Target mRNAs, inhibit microRNAs, or silence lncRNAs using one unified technology for functional genomics, target discovery, and validation.
AUM BioTech's RNA Silencing Products
Specialized solutions for every RNA silencing need
Self-delivering Antisense Oligonucleotides (sdASO™)
AUM BioTech's premium products that enter cells without transfection reagents
AUMsilence™
mRNA Knockdown Oligos
Specialized antisense molecules designed for potent mRNA silencing in virtually any cell type, with up to 95% knockdown efficiency.
AUMantagomir™
miRNA Inhibition Oligos
Tailored for microRNA inhibition, allowing researchers to block specific miRNAs and reveal their biological functions or therapeutic potential.
AUMlnc™
lncRNA Knockdown Oligos
Specifically optimized to bind and degrade lncRNA transcripts, including nuclear-retained RNAs beyond the reach of traditional RNAi.
AUMblock™
Blocker Oligos
Steric-blocking antisense molecules designed to bind target RNAs and modulate their function without inducing RNA cleavage.
AUMskip™
Exon Skipping ASOs
Specialized antisense oligonucleotides designed to bind pre-mRNA and redirect splicing, typically by causing a specific exon to be skipped during mRNA processing.
AUMsilence V+™
Viral RNA Knockdown Oligos
Dedicated solution for viral RNA silencing, accelerating virology research and antiviral therapeutic discovery.
Transfection-Optimized ASOs (toASO™)
Budget-friendly options for cost-effective research
AUMsaver™
Cost-Effective ASOs
Budget-friendly gene silencing ASOs optimized for standard transfection protocols, offering high potency and specificity at an accessible price point for high-throughput screening and routine lab work.
Experience the AUM BioTech Difference
Join researchers worldwide achieving breakthrough discoveries with AUMsilence sdASO RNA silencing platform
Transforming Research Across Multiple Fields
Cancer Research
Target oncogenes and tumor suppressors in solid tumors, liquid cancers, and metastatic models with unprecedented precision
Neurodegenerative Diseases
Study Alzheimer's, Parkinson's, ALS, and Huntington's disease mechanisms in neurons and glial cells
Viral Infections
Investigate host-pathogen interactions and antiviral targets for COVID-19, HIV, influenza, and emerging viruses
Immunology
Modulate immune responses in T cells, B cells, macrophages, and dendritic cells for therapeutic discovery
Stem Cell Biology
Control cell fate decisions, iPSC differentiation, and developmental pathways with reversible gene silencing
Gene Regulation
Dissect miRNA networks, lncRNA functions, and regulatory cascades in any cellular context
Why Leading Labs Choose AUM BioTech
Superior Reproducibility
Consistent knockdown across experiments with minimal batch-to-batch variation
Rapid Results
Achieve gene silencing in 24-72 hours without time-consuming optimization
Cost-Effective
Reduce experimental costs with no need for expensive transfection reagents or equipment
Proven Success
Validated in hundreds of peer-reviewed publications across diverse research areas
Ready to accelerate your research?
Expert Consultation
Get personalized guidance for your RNA silencing experiments
- Free expert consultation
- Custom protocol development
- In vivo optimization support
Join the RNA Revolution with AUM BioTech
Ready to elevate your research to the next level? Explore our product pages to find the right gene-silencing solution for your needs, or contact our scientific team for a consultation on how AUM's technology can advance your specific project.